Description
A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpenes, 1-O-acetylbritannilactone (1), britannilactone (2) and neobritannilactone B (3). Compounds 1 and 2 significantly reduced melanin production in a dose-dependent manner with IC50 values of 13.3 and 15.5 μM, respectively.
Synonyms
Desacetylinulicin
Molecular Formula
C15H22O4
Canonical SMILES
CC1=C(C(C2C(C1)OC(=O)C2=C)O)C(C)CCCO
InChI
InChI=1S/C15H22O4/c1-8(5-4-6-16)12-9(2)7-11-13(14(12)17)10(3)15(18)19-11/h8,11,13-14,16-17H,3-7H2,1-2H3/t8-,11+,13+,14+/m0/s1
InChIKey
ASZIGQFYGXSPCO-UBVLEBKSSA-N