Bonducellin

Flavonoids

NP2129

83162-84-9

Bonducellin

Bonducellin is isolated from the herbs of Caesalpinia spinosa. Bonducellin shows weak antiproliferative against A2780 human ovarian cancer cell line with the IC50 value of 10.6 uM. Bonducellin has anti-inflammatory activities that can significantly and dose-dependently inhibit the inflammatory mediators: nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity.

(E)-7-Hydroxy-3-(4-methoxybenzylidene)chroman-4-one; 2,3-dihydro-7-hydroxy-3-[(4-methoxyphenyl)methylene]-4H-1-benzopyran-4-one

(3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]chromen-4-one

282.29

C17H14O4

COC1=CC=C(C=C1)C=C2COC3=C(C2=O)C=CC(=C3)O

InChI=1S/C17H14O4/c1-20-14-5-2-11(3-6-14)8-12-10-21-16-9-13(18)4-7-15(16)17(12)19/h2-9,18H,10H2,1H3/b12-8+

DLQSYZMPSWHYMW-XYOKQWHBSA-N

526.3±50.0 °C (Predicted)

98.0%

1.318±0.06 g/cm3 (Predicted)

Powder

Powder