(+)-Bicuculline

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0513
CAS
485-49-4
Product Name
(+)-Bicuculline
Structure

Product Details

Description
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.
Synonyms
Bicculine; Bicucullin; BRN 0098786; NSC 32192; BRN0098786; NSC32192; BRN-0098786; NSC-32192
IUPAC Name
(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
Molecular Weight
367.35
Molecular Formula
C20H17NO6
Canonical SMILES
CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
InChI
InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Melting Point
192-196 °C.
Purity
98 % (HPLC)
Density
1.473 g/cm3
Solubility
Benzene, chloroform, ethyl acetate, sparingly in alcohol and ether, practically not in water
Appearance
Pale yellow solid
Storage
Store at room temperature, in dry and dark place.
Color
Orange
Form
Powder
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