(+)-Bicuculline

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0513

CAS

485-49-4

Product Name

(+)-Bicuculline

Structure

Product Details

Description

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.

Synonyms

Bicculine; Bicucullin; BRN 0098786; NSC 32192; BRN0098786; NSC32192; BRN-0098786; NSC-32192

IUPAC Name

(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one

Molecular Weight

367.35

Molecular Formula

C20H17NO6

Canonical SMILES

CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3

InChI

InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChIKey

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

Melting Point

192-196 °C.

Purity

98 % (HPLC)

Density

1.473 g/cm3

Solubility

Benzene, chloroform, ethyl acetate, sparingly in alcohol and ether, practically not in water

Appearance

Pale yellow solid

Storage

Store at room temperature, in dry and dark place.

Color

Orange

Form

Powder

Products

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