Betulinic acid

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For Research Use Only.

Size	Price	Stock	Quantity
10 g	$365	In stock
100 g	$1499	In stock

Category

Triterpenoids

Cat.No.

NP6980

CAS

472-15-1

Product Name

Betulinic acid

Structure

Product Details

Description

Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material.

Synonyms

ALS357; ALS 357; ALS-357; Mairin; Lupatic Acid; 3beta-Hydroxy-20(29)-lupaene-28-oic acid

IUPAC Name

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Molecular Weight

456.70

Molecular Formula

C30H48O3

Canonical SMILES

CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O

InChI

InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1

InChIKey

QGJZLNKBHJESQX-FZFNOLFKSA-N

Boiling Point

550.0±33.0 °C at 760 mmHg

Melting Point

295-298 °C (dec.)(lit.)

Flash Point

300.5±21.9 °C

Purity

98%

Density

1.1±0.1 g/cm3

Solubility

In Vitro:
DMSO : 35.71 mg/mL(78.19 mM;Need ultrasonic)
In Vivo:
1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline
Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic
2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline)
Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic
3.Add each solvent one by one:10% DMSO >> 90%corn oil
Solubility: ≥ 2.08 mg/mL (4.55 mM); Clear solution

Appearance

White to off-white Solid

Application

Anti-melanogenic/antitumor/anti-HIV

Storage

4°C, protect from light
* In solvent :
-80°C, 6 months
-20°C, 1 month (protect from light)

Form

Powder

Packaging

10 g

Vapor Pressure

0.0±3.4 mmHg at 25°C