Berbamine

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0583
CAS
478-61-5
Product Name
Berbamine
Structure

Product Details

Description
Berbamine isolated from the roots of Cocculus orbiculatus (L.) DC. It may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia.
Synonyms
6,6',7-trimethoxy-2,2'-dimethyl-berbaman-12-o;
IUPAC Name
(1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
Molecular Weight
608.7
Molecular Formula
C37H40N2O6
Canonical SMILES
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
InChI
InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1
InChIKey
DFOCUWZXJBAUSQ-URLMMPGGSA-N
Purity
98%
Appearance
Powder
Application
antihypertensive; antibacterial;
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