Berbamine

Inquiry

For Research Use Only.

Category

Alkaloids

Cat.No.

NP0583

CAS

478-61-5

Product Name

Berbamine

Structure

Product Details

Description

Berbamine isolated from the roots of Cocculus orbiculatus (L.) DC. It may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia.

Synonyms

6,6',7-trimethoxy-2,2'-dimethyl-berbaman-12-o;

IUPAC Name

(1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol

Molecular Weight

608.7

Molecular Formula

C37H40N2O6

Canonical SMILES

CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC

InChI

InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1

InChIKey

DFOCUWZXJBAUSQ-URLMMPGGSA-N

Purity

98%

Appearance

Powder

Application

antihypertensive; antibacterial;

Form

Powder

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