Description
Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression.
Synonyms
1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one
IUPAC Name
1,5,8-trihydroxy-3-methoxyxanthen-9-one
Molecular Formula
C14H10O6
Canonical SMILES
COC1=CC(=C2C(=C1)OC3=C(C=CC(=C3C2=O)O)O)O
InChI
InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3
InChIKey
JDIORNFCMMYMLF-UHFFFAOYSA-N
Boiling Point
580.2±50.0 °C at 760 mmHg
Flash Point
228.0±23.6 °C
Solubility
In vitro:
10 mM in DMSO
Storage
Powder:
-20°C 3 years
4°C 2 years
In solvent:
-80°C 6 months
-20°C 1 months
Vapor Pressure
0.0±1.7 mmHg at 25°C