Asebogenin

For Research Use Only.
Category
Chalcones
Cat.No.
NP0950
CAS
520-42-3
Product Name
Asebogenin
Structure

Product Details

Description
Asebogenin is extracted from the leaves of Pieris japonica. It can inhibit the proliferation of murine B cells. It displays antiplasmodial activities against both a resistant strain and a chloroquine-sensitive of Plasmodium falciparum. It also shows anti-bacterial activity. It inhibits methicillin-resistant S. aureus and S. aureus with IC50 values of 4.5 and 10 micrograms/ml respectively. It is a predicted metabolite generated by BioTransformer. It is generated through an o-dealkylation reaction, which occurs in humans and is generated by cyp1a2, cyp2c9 and cyp2c19 enzymes.
Synonyms
1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-1-propanone; 4'-O-Methylphloretin; 2',6',4-Trihydroxy-4'-methoxydihydrochalcone; Phloretin 4'-methyl ether
IUPAC Name
1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
Molecular Weight
288.29
Molecular Formula
C16H16O5
Canonical SMILES
COC1=CC(=C(C(=C1)O)C(=O)CCC2=CC=C(C=C2)O)O
InChI
InChI=1S/C16H16O5/c1-21-12-8-14(19)16(15(20)9-12)13(18)7-4-10-2-5-11(17)6-3-10/h2-3,5-6,8-9,17,19-20H,4,7H2,1H3
InChIKey
UPXIBKPHJYQSGP-UHFFFAOYSA-N
Boiling Point
550.9±50.0°C (Predicted)
Melting Point
168°C
Purity
98.5%
Density
1.325±0.06 g/cm3(Predicted)
Appearance
Powder
Definition
ChEBI: A member of the class of dihydrochalcones that is the 4'-methyl ether derivative of phloretin.
Form
Powder
pKa
7.00±0.40(Predicted)
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