Description
Arctigenin is the aglycone of arctiin and is a lignan found in certain plants of the Asteraceae. It has shown antiviral and anticancer effects in glass. It showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). It selectively altered the phosphorylation of members of the MAPK superfamily, decreasing phosphorylation of ERK1/2 and activated phosphorylation of p38 significantly in a dose-dependent manner.
Molecular Formula
C21H24O6
Canonical SMILES
COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
InChI
InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
InChIKey
NQWVSMVXKMHKTF-JKSUJKDBSA-N
Boiling Point
567.0±45.0 °C at 760 mmHg
Solubility
water, 23.08 mg/L @ 25 °C (est)
Application
Antioxidant/anti-inflammatory/antiproliferative/antiviral
Vapor Pressure
0.0±1.6 mmHg at 25°C