Andrographolide

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For Research Use Only.

Size	Price	Stock	Quantity
50 g	$269	In stock
100 g	$515	In stock

Category

Diterpenoids

Cat.No.

NP1507

CAS

5508-58-7

Product Name

Andrographolide

Structure

Product Details

Description

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. It has the effects of dispelling heat, detoxification, anti-inflammatory and relieving pain.

Synonyms

(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methyle
ne-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxy-2-oxolanone

Molecular Weight

350.45

Molecular Formula

C20H30O5

Canonical SMILES

CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

InChI

InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChIKey

BOJKULTULYSRAS-OTESTREVSA-N

Boiling Point

557.3±50.0 °C at 760 mmHg

Melting Point

229-232°C

Flash Point

195.5±23.6 °C

Purity

>98%

Density

1.21g/cm3

Solubility

In Vitro:
DMSO : 100 mg/mL(285.35 mM;Need ultrasonic)
H2O : < 0.1 mg/mL(insoluble)
In Vivo:
1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution
2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline)
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution
3.Add each solvent one by one:10% DMSO >> 90%corn oil
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution

Appearance

Powder

Application

anticancer

Storage

Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month

Color

Yellow

Form

Powder

Packaging

50 g / 100 g