Ambrisentan

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For Research Use Only.

Size	Price	Stock	Quantity
50 mg	$197	In stock

Category

Impurities

Cat.No.

NP3038

CAS

177036-94-1

Product Name

Ambrisentan

Structure

Product Details

Description

Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).

Synonyms

BSF-208075; BSF208075; BSF 208075; LU-208075; LU208075; LU 208075; Letairis; Volibris

IUPAC Name

(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid

Molecular Weight

378.42

Molecular Formula

C22H22N2O4

Canonical SMILES

CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

InChI

InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

InChIKey

OUJTZYPIHDYQMC-LJQANCHMSA-N

Melting Point

>150 °C

Purity

>98%

Solubility

Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH.

Appearance

White to off white solid

Application

Antihypertensive Agents

Form

Powder

Packaging

50 mg

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