9-Aminocamptothecin

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0052
CAS
91421-43-1
Product Name
9-Aminocamptothecin
Structure

Product Details

Description
9-Aminocamptothecin is a water-insoluble camptothecin derivative and an inhibitor of the nuclear enzyme topoisomerase I, disrupting the repair of single-strand DNA breakages.
Synonyms
9-amino-camptothecin; 9-amino-CPT; 9-AC; 9-amino-20(S)-camptothecin; 9-amino-20-camptothecin; Aminocamptothecin
IUPAC Name
(19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Molecular Weight
363.37
Molecular Formula
C20H17N3O4
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O
InChI
InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
Boiling Point
819.6±65.0°C (Predicted)
Melting Point
142.0-145.0°C
Flash Point
449.5°C
Purity
>98%
Density
1.55±0.1 g/cm3(Predicted)
Solubility
Soluble in DMSO.
Appearance
Powder
Application
Antineoplastic Agents
Storage
2-8°C (Protect from light)
Color
Off-white
Form
Solid
HS Code
29349990
MDL
MFCD00909855
Merck
14,431
Packaging
100 mg
pKa
11.23±0.20(Predicted)
Refractive Index
1.771
RTECS
UQ0490500
Uses
9-Amino Camptothecin is a derivative of Camptothecin, as antitumor agent.
Water Solubility
Insoluble in water.
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