4,4'-DIHYDROXY-2-METHOXYCHALCONE

For Research Use Only.
Category
Chalcones
Cat.No.
NP0936
CAS
34221-41-5
Product Name
4,4'-DIHYDROXY-2-METHOXYCHALCONE
Structure

Product Details

Description
Echinatin is extracted from the root of Glycyrrhiza glabra L. It inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. It disturbs the mitochondrial energy transfer reactions and membrane permeability. It was demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.
Synonyms
(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; (E)-4,4'-Dihydroxy-2-methoxychalcone; 4,4'-Dihydroxy-2-methoxy-trans-chalcone; 4'-Dihydroxy-2-Methoxychalcone; Retrochalcone
IUPAC Name
(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Molecular Weight
270.28
Molecular Formula
C16H14O4
Canonical SMILES
COC1=C(C=CC(=C1)O)C=CC(=O)C2=CC=C(C=C2)O
InChI
InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+
InChIKey
QJKMIJNRNRLQSS-WEVVVXLNSA-N
Boiling Point
509.8±50.0°C (Predicted)
Melting Point
210°C (dec.)
Purity
>98%
Density
1.282±0.06 g/cm3 (20°C 760 Torr)
Appearance
White powder
Storage
2-8°C
Form
Oil
Packaging
10 mg
pKa
7.82±0.15(Predicted)
Uses
Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
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