4,4'-DIHYDROXY-2-METHOXYCHALCONE

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For Research Use Only.

Size	Price	Stock	Quantity
10 mg	$299	In stock

Category

Chalcones

Cat.No.

NP0936

CAS

34221-41-5

Product Name

4,4'-DIHYDROXY-2-METHOXYCHALCONE

Structure

Product Details

Description

Echinatin is extracted from the root of Glycyrrhiza glabra L. It inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. It disturbs the mitochondrial energy transfer reactions and membrane permeability. It was demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.

Synonyms

(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; (E)-4,4'-Dihydroxy-2-methoxychalcone; 4,4'-Dihydroxy-2-methoxy-trans-chalcone; 4'-Dihydroxy-2-Methoxychalcone; Retrochalcone

IUPAC Name

(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

Molecular Weight

270.28

Molecular Formula

C16H14O4

Canonical SMILES

COC1=C(C=CC(=C1)O)C=CC(=O)C2=CC=C(C=C2)O

InChI

InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

InChIKey

QJKMIJNRNRLQSS-WEVVVXLNSA-N

Boiling Point

509.8±50.0°C (Predicted)

Melting Point

210°C (dec.)

Purity

>98%

Density

1.282±0.06 g/cm3 (20ºC 760 Torr)

Appearance

White powder

Storage

2-8°C

Form

Oil

Packaging

10 mg

pKa

7.82±0.15(Predicted)

Uses

Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

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