4,4'-Diaminodiphenylsulfone

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For Research Use Only.

Size	Price	Stock	Quantity
1 kg	$299	In stock

Category

Impurities

Cat.No.

NP2822

CAS

80-08-0

Product Name

4,4'-Diaminodiphenylsulfone

Structure

Product Details

Description

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. It is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects. It also inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase.

Synonyms

4-(4-aminophenyl)sulfonylaniline

IUPAC Name

4-(4-aminophenyl)sulfonylaniline

Molecular Weight

248.30

Molecular Formula

C12H12N2O2S

Canonical SMILES

C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N

InChI

InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

InChIKey

MQJKPEGWNLWLTK-UHFFFAOYSA-N

Boiling Point

511.7 ℃ at 760 mmHg

Melting Point

175.5 ℃

Flash Point

263.2ºC

Purity

> 98 %

Density

1.361 g/cm³

Solubility

>37.2 ug/mL

Appearance

White crystalline powder

Application

anti-inflammatory agent

Storage

-20ºC Freezer

EINECS

201-248-4

Form

Powder

Hazard Class

6.1(b)

Hazard Codes

HS Code

29051620

MDL

MFCD00007887

Packaging

1 kg

RIDADR

UN 3249

Risk Statements

R22

RTECS

BY8925000

Safety Statements

S22

Stability

Stable. Combustible. Incompatible with strong oxidizing agents.

Vapor Pressure

0.00000003 [mmHg]

WGK Germany

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