4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

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For Research Use Only.

Category

Impurities

Cat.No.

NP2695

CAS

284462-37-9

Product Name

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

Structure

Product Details

Description

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is an intermediate of Sorafenib, which is a kinase inhibitor drug used for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma.

Synonyms

4-(4-Aminophenoxy)-N-methylpicolinamide; 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline; 4-[(4-aminomethyl)phenoxy]-2-pyridine carbonic acid methylamide; Sorafenib Imp -1; Sorafenib Related Compound 23

IUPAC Name

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Molecular Weight

243.26

Molecular Formula

C13H13N3O2

Canonical SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)N

InChI

InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)

InChIKey

RXZZBPYPZLAEFC-UHFFFAOYSA-N

Boiling Point

476.8±40.0°C (Predicted)

Melting Point

110-112°C

Purity

≥95%

Density

1.241±0.06 g/cm³ (Predicted)

Solubility

Soluble in DMSO (Slightly), Methanol (Slightly)

Appearance

Light brown to brown solid

Storage

Store at 2-8°C

Form

Powder

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