3,4',5-Trimethoxystilbene

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For Research Use Only.

Category

Phenols

Cat.No.

NP4562

CAS

22255-22-7

Product Name

3,4',5-Trimethoxystilbene

Structure

Product Details

Description

3,4',5-Trimethoxystilbene is isolated from the herbs of Virola cuspidata. 3,4',5-Trimethoxystilbene exerts antiallergic and anti-mitotic properties. It shows antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. 3,4',5-Trimethoxystilbene is a potent small molecule inducer of autophagy in human umbilical vascular endothelial cells (HUVECs) in the presence of serum. It has anti-inflammatory activity, the ability of it to induce HO-1 expression may provide one of possible mechanisms of its anti-inflammatory action. 3,4',5-Trimethoxystilbene shows potent antitumor and anti-HCV activities without exhibiting cytotoxicity to human hepatocytes in vitro or in mice livers. It acts as an inhibitor of tubulin polymerization.

Synonyms

Resveratrol trimethyl ether

IUPAC Name

1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene

Molecular Weight

270.32

Molecular Formula

C17H18O3

Canonical SMILES

COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC

InChI

InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+

InChIKey

GDHNBPHYVRHYCC-SNAWJCMRSA-N

Boiling Point

423.8±35.0 °C(Predicted)

Melting Point

57°C

Purity

98.0%

Density

1.104±0.06 g/cm3(Predicted)

Solubility

DMSO: ≥34mg/mL

Appearance

Powder

Storage

Sealed in dry,2-8°C

Chemical Properties

Pale Yellow Oil

Color

White to tan

EINECS

694-659-7

Hazard Class

Xi,N

RIDADR

UN 3077 9 / PGIII

Risk Statements

36/37/38-50/53-41-37/38

Safety Statements

26-36/37/39-61-60-39

Uses

A resveratrol analog with a variety of pharmacology action, including anti-cancer properties, anti-allergic activity, estrogenic activity, antiangiogenic activity, and vascular-targeting activity against microtubule-destabilization

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