2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE

For Research Use Only.
Category
Chalcones
Cat.No.
NP0957
CAS
3420-72-2
Product Name
2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE
Structure

Product Details

Description
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.
Synonyms
Flavokawain A; 2'-Hydroxy-4,4',6'-trimethoxychalcone; 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
IUPAC Name
(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
Molecular Weight
314.33
Molecular Formula
C18H18O5
Canonical SMILES
COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O
InChI
InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
InChIKey
CGIBCVBDFUTMPT-RMKNXTFCSA-N
Boiling Point
529.9 °C at 760 mmHg
Melting Point
112-116°C(lit.)
Purity
> 95 %
Density
1.207 g/cm3
Solubility
Chloroform (Slightly), Methanol (Slightly)
Appearance
Yellow powder
Application
anti-tumor activity; anti-inflammatory
Storage
2-8°C
Form
Powder
Hazard Codes
Xi
MDL
MFCD00017174
pKa
6.78±0.40(Predicted)
Risk Statements
36/37/38
Safety Statements
26-36
Uses
2'-Hydroxy-4,4',6'-trimethoxychalcone may be used to synthesize 2',2"'-dihydroxy-4,4',4'',4"',6',6'''-hexamethoxy[5',5''']bichalcone and 3'-bromo-4,4',6'-trimethoxy-2'-hydroxychalcone.
WGK Germany
3
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