2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE

Inquiry

For Research Use Only.

Category

Chalcones

Cat.No.

NP0957

CAS

3420-72-2

Product Name

2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE

Structure

Product Details

Description

(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.

Synonyms

Flavokawain A; 2'-Hydroxy-4,4',6'-trimethoxychalcone; 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

IUPAC Name

(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

Molecular Weight

314.33

Molecular Formula

C18H18O5

Canonical SMILES

COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O

InChI

InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+

InChIKey

CGIBCVBDFUTMPT-RMKNXTFCSA-N

Boiling Point

529.9 ℃ at 760 mmHg

Melting Point

112-116°C(lit.)

Purity

> 95 %

Density

1.207 g/cm³

Solubility

Chloroform (Slightly), Methanol (Slightly)

Appearance

Yellow powder

Application

anti-tumor activity; anti-inflammatory

Storage

2-8°C

Form

Powder

Hazard Codes

MDL

MFCD00017174

pKa

6.78±0.40(Predicted)

Risk Statements

36/37/38

Safety Statements

26-36

Uses

2'-Hydroxy-4,4',6'-trimethoxychalcone may be used to synthesize 2',2"'-dihydroxy-4,4',4'',4"',6',6'''-hexamethoxy[5',5''']bichalcone and 3'-bromo-4,4',6'-trimethoxy-2'-hydroxychalcone.

WGK Germany

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