2-Fluoroadenosine

Impurities

NP3159

146-78-1

2-Fluoroadenosine

Fludarabine is highly effective in the treatment of chronic lymphocytic leukemia, producing higher response rates than alkylating agents such as chlorambucil alone.Fludarabine is used in various combinations with cyclophosphamide, mitoxantrone, dexamethasone and rituximab in the treatment of indolent non-Hodgkins lymphomas. As part of the FLAG regimen, fludarabine is used together with cytarabine and granulocyte colony-stimulating factor in the treatment of acute myeloid leukaemia. Because of its immunosuppressive effects, fludarabine is also used in some conditioning regimens prior to non myeloablative allogeneic stem cell transplant.

Fludarabine; 2-Fluoro Adenosine; 6-Amino-2-fluoro-9-beta-D-ribofuranosylpurine

(2R,3R,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

285.235

C10H12FN5O4

C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)F

InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

HBUBKKRHXORPQB-UUOKFMHZSA-N

747.3°C at 760 mmHg

240°C

98%

2.17 g/cm3

>42.8 [ug/mL] (The mean of the results at pH 7.4)

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Store at 2-8°C (under dark)

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