(2β,5α,12β,19α)-4β-(Acetyloxy)-6,7-didehydro-3β-hydroxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

For Research Use Only.
Category
Alkaloids
Cat.No.
NP0439
CAS
5231-60-7
Product Name
(2β,5α,12β,19α)-4β-(Acetyloxy)-6,7-didehydro-3β-hydroxy-1-methylaspidospermidine-3-carboxylic acid methyl ester
Structure

Product Details

Description
Vindorosine usually comes from the herbs of Catharanthus roseus (L.) G. Don. Vindorosine treated with different pharmacological blockers and inhibitors for the measurement of vascular reactivity on a Multi Myograph System. Blood vessel relaxation by Vindorosine and the possible underlying mechanisms involved the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
Synonyms
(2β,5α,12β,19α)-4β-(Acetyloxy)-6,7-didehydro-3β-hydroxy-1-methylaspidospermidine-3-carboxylic acid methyl ester; Demethoxyvindoline; Vindolidin; Vindolidine; Vindorosin
IUPAC Name
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
Molecular Weight
426.5
Molecular Formula
C24H30N2O5
Canonical SMILES
CCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=CC=CC=C45)C
InChI
InChI=1S/C24H30N2O5/c1-5-22-11-8-13-26-14-12-23(18(22)26)16-9-6-7-10-17(16)25(3)19(23)24(29,21(28)30-4)20(22)31-15(2)27/h6-11,18-20,29H,5,12-14H2,1-4H3/t18-,19+,20+,22+,23+,24-/m0/s1
InChIKey
SASWULSUPROHRT-MCIGMTSASA-N
Melting Point
167°C
Purity
>98%
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