Lucidone

Chalcones

NP0953

19956-53-7

Lucidone

Lucidone, coming from the root of Lindera strychnifolia, may possess antioxidant and anti-inflammatory properties and may be useful for the prevention of free radical-induced skin damage. The anti-inflammatory activity of lucidone might cause by the inhibition of iNOS and COX-2 expressions through the down-regulation of NF-κB and AP-1 binding activity. Besides, the effects of lucidone on tyrosinase and antimelanogenic activity were investigated, lucidone strongly inhibits the activity of mushroom tyrosinase. The antimelanogenic activity of lucidone is probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF expression.

Lucidone;19956-53-7;3-hydroxy-4-methoxy-2-[(E)-3-phenylprop-2-enoyl]cyclopenta-2,4-dien-1-one;4-Cyclopentene-1,3-dione, 2-(1-hydroxy-3-phenyl-2-propenylidene)-4-methoxy-, (Z,E)-;SCHEMBL6846053;CHEBI:183569;LMPK12120439;AKOS032948482;AKOS040744744;FS-9524;4-Cyclopentene-1,3-dione, 2-[(2E)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-, (2Z)-;DA-65101;(2Z)-2-[(2E)-1-hydroxy-3-phenylprop-2-en-1-ylidene]-4-methoxycyclopent-4-ene-1,3-dione;4-Cyclopentene-1,3-dione, 2-(-hydroxycinnamylidene)-4-methoxy- (8CI); (2Z)-2-[(2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione;

3-hydroxy-4-methoxy-2-[(E)-3-phenylprop-2-enoyl]cyclopenta-2,4-dien-1-one

486.7

C30H46O5

C[C@@H]1C[C@@H]2[C@H](O[C@]3([C@H]1[C@]4(CC[C@@]56C[C@@]57CCC(=O)C([C@@H]7CC[C@H]6[C@@]4([C@H]3O)C)(C)C)C)O2)C(C)(C)O

InChI=1S/C15H12O4/c1-19-13-9-12(17)14(15(13)18)11(16)8-7-10-5-3-2-4-6-10/h2-9,18H,1H3/b8-7+

ANPTXNYQLGJVRE-BQYQJAHWSA-N

489.6±45.0°C (Predicted)

166.5-168.5°C

>98%

1.30±0.1 g/cm3(Predicted)

Solid

Antimelanogenic/antioxidant/anti-inflammatory

-20°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Powder

4.50±1.00(Predicted)